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STA-9584

CAT: 0931-T68400-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68400-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
906481-23-0
Target
Others
Related Pathways
Others
Bioactivity
STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5- (5- (3,4,5-trimethoxyphenyl) isoxazol-4-yl) aniline (STA-9122) (active metabolite of STA-9584) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P) .
Smiles
Cl.COc1ccc(cc1NC(=O)[C@@H](N)Cc1ccccc1)-c1cnoc1-c1cc(OC)c(OC)c(OC)c1
Molecular Formula
C28H29N3O6
Molecular Weight
503.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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