STA-9584

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5- (5- (3,4,5-trimethoxyphenyl) isoxazol-4-yl) aniline (STA-9122) (active metabolite of STA-9584) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P) .

• Smiles:

  Cl.COc1ccc(cc1NC(=O)[C@@H](N)Cc1ccccc1)-c1cnoc1-c1cc(OC)c(OC)c(OC)c1

• Molecular Formula:

  C28H29N3O6

• Molecular Weight:

  503.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  906481-23-0