StA-IFN-1

CAT: 0931-MF-0046103-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0046103-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
300839-31-0
Target
Others|||IFNAR
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 ?M in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKK? component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-?, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
Smiles
CC(=O)n1cc(C2C(=O)NN=C2C)c2ccccc12
Molecular Formula
C14H13N3O2
Molecular Weight
255.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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