StA-IFN-1

CAT: 0931-T38158-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T38158-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

300839-31-0

Target

Others, IFNAR

Related Pathways

Immunology/Inflammation, Others

Bioactivity

StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.

Smiles

CC(=O)n1cc(C2C(=O)NN=C2C)c2ccccc12

Molecular Formula

C14H13N3O2

Molecular Weight

255.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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