StA-IFN-1

• Target:

  Others|||IFNAR

• Related Pathways:

  Immunology/Inflammation|||Others

• Bioactivity:

  StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 ?M in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKK? component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-?, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.

• Smiles:

  CC (=O) n1cc (C2C (=O) NN=C2C) c2ccccc12

• Molecular Formula:

  C14H13N3O2

• Molecular Weight:

  255.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  300839-31-0