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EHT-6706

CAT: 0931-T70906-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70906-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1351592-10-3
Target
Others
Related Pathways
Others
Bioactivity
EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell monolayers and inhibits endothelial cell migration. Genome-wide transcriptomic analysis of EHT 6706 effects on human endothelial cells shows that the antiangiogenic activity elicits gene deregulations of antiangiogenic pathways. These findings indicate that EHT 6706 is a promising tubulin-binding compound with potentially broad clinical antitumor efficacy.
Smiles
C(C=1C2=C(C(N)=C(OCC)C=C2)C=NC1)C3=CC(OC)=C(OC)C(OC)=C3
Molecular Formula
C21H24N2O4
Molecular Weight
368.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

7-Ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine

a tubulin-binding agent with antineoplastic activity

CAS Number1351592-10-3
PubChem CID54760530
IUPAC Name7-ethoxy-4-[(3,4,5-trimethoxyphenyl)methyl]isoquinolin-8-amine
Molecular FormulaC21H24N2O4
Molecular Weight368.4
XLogP3.6
Topological Polar Surface Area75.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity438
SMILES
CCOC1=C(C2=C(C=C1)C(=CN=C2)CC3=CC(=C(C(=C3)OC)OC)OC)N
InChI
InChI=1S/C21H24N2O4/c1-5-27-17-7-6-15-14(11-23-12-16(15)20(17)22)8-13-9-18(24-2)21(26-4)19(10-13)25-3/h6-7,9-12H,5,8,22H2,1-4H3
InChIKey
INAKKEXXSTWCKJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-Ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine
CAS: 1351592-10-3
CID: 54760530
Formula: C21H24N2O4
MW: 368.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.4
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass368.17360725
Monoisotopic Mass368.17360725
Topological Polar Surface Area75.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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