Products for Research Use Only
RegisterLogin

EHT 5372

CAT: 0804-HY-111379-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-111379-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EHT 5372 is a highly potent and selective inhibitor of DYRK's family kinases with IC50s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, and 221 nM for DYRK1A, DYRK1B, DYRK2, DYRK3, CLK1, CLK2, CLK4, GSK-3α, and GSK-3β, respectively[1][2].
CAS Number
1425945-63-6
UNSPSC
12352005
Target
CDK; DYRK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eht-5372.html
Purity
98.12
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N=C(C(S1)=NC2=C1C3=C(NC4=CC=C(Cl)C=C4Cl)N=CN=C3C=C2)OC
Molecular Formula
C17H11Cl2N5OS
Molecular Weight
404.27
References & Citations
[1]Séverine Coutadeur, et al. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. J Neurochem. 2015 May;133 (3) :440-51.|[2]Apirat Chaikuad, et al. An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases. J Med Chem. 2016 Nov 23;59 (22) :10315-10321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; DYRK1; DYRK2; DYRK4; GSK-3α; GSK-3β

Chemical Information

Methyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
CAS Number1425945-63-6
PubChem CID71529610
IUPAC Namemethyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
Molecular FormulaC17H11Cl2N5OS
Molecular Weight404.3
XLogP5.4
Topological Polar Surface Area112
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity529
SMILES
COC(=N)C1=NC2=C(S1)C3=C(C=C2)N=CN=C3NC4=C(C=C(C=C4)Cl)Cl
InChI
InChI=1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
InChIKey
QSGKPYRFWJINEH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methyl 9-(2,4-dichloroanilino)-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
CAS: 1425945-63-6
CID: 71529610
Formula: C17H11Cl2N5OS
MW: 404.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight404.3
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass403.0061366
Monoisotopic Mass403.0061366
Topological Polar Surface Area112 Ų
Heavy Atom Count26
Formal Charge0
Complexity529
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-16659-01EHT 1864
HY-111380-01EHT 1610
HY-W953544CRBN ligand-537
HY-P11145Influenza HA (529-537)

Alternative Products

CatalogName
T61985-01EHT 5372
A12586-5EHT 5372 5mg
A12586-10EHT 5372 10mg
A12586-200EHT 5372 200mg
A12586-50EHT 5372 50mg
A12586-25EHT 5372 25mg
A12586-100EHT 5372 100mg
A12586-1EHT 5372 1mg
SR303592PMM1 Human siRNA Oligo Duplex (Locus ID 5372)
TL310339VPMM1 Human shRNA Lentiviral Particle (Locus ID 5372)

Popular Products