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Zotiraciclib HCl

CAT: 0931-T70897-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70897-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1354567-82-0
Target
FLT, JAK, Others, CDK
Related Pathways
Others, Chromatin/Epigenetic, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Cell Cycle/Checkpoint, Stem Cells
Bioactivity
Zotiraciclib, also known as TG02 and SB1317, is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9) . It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
Molecular Formula
C23H26Cl2N4O
Molecular Weight
445.388
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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