KR-67607

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  KR-67607, also known as NTX-101 is novel selective 11?-hydroxysteroid dehydrogenase 1 (11?-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma.

• Smiles :

  C(N)(=O)C12C[C@@]3([C@@H](NC(CN4S(=O)(=O)N(CC(C)C4)C5=C(Cl)C=C(C(F)(F)F)C=C5Cl)=O)[C@](C1)(CC(C2)C3)[H])[H]

• Molecular Formula :

  C24H29Cl2F3N4O4S

• Molecular Weight :

  597.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1401564-00-8