KR-39038

• Target:

  Others|||GRK|||HDAC

• Related Pathways:

  Chromatin/Epigenetic|||Others|||DNA Damage/DNA Repair|||GPCR/G Protein

• Bioactivity:

  KR-39038 is an orally active GRK5 (G protein-coupled receptor kinase 5) inhibitor (IC50: 0.02 ?M) that inhibits the HDAC5 pathway in neonatal cardiomyocytes and significantly reduces angiotensin II-induced hypertrophy, leading to notable anti-myocardial hypertrophy effects and improved cardiac function. KR-39038 is applicable for heart failure research.

• Smiles:

  O=C1N=C(NC2=CC(NCCCNCCCCNCCCN)=C(F)C=C12)C=3C=CC=CC3Cl

• Molecular Formula:

  C24H32ClFN6O

• Molecular Weight:

  475

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2770300-35-9