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KR-39038

CAT: 0931-T64266-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64266-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2770300-35-9
Target
Others, GRK, HDAC
Related Pathways
Chromatin/Epigenetic, Others, DNA Damage/DNA Repair, GPCR/G Protein
Bioactivity
KR-39038 is an orally active GRK5 (G protein-coupled receptor kinase 5) inhibitor (IC50: 0.02 μM) that inhibits the HDAC5 pathway in neonatal cardiomyocytes and significantly reduces angiotensin II-induced hypertrophy, leading to notable anti-myocardial hypertrophy effects and improved cardiac function. KR-39038 is applicable for heart failure research.
Smiles
O=C1N=C(NC2=CC(NCCCNCCCCNCCCN)=C(F)C=C12)C=3C=CC=CC3Cl
Molecular Formula
C24H32ClFN6O
Molecular Weight
475
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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