Products for Research Use Only
RegisterLogin

KAI-407

CAT: 0931-T70507-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T70507-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1513879-18-9
Target
Others
Related Pathways
Others
Bioactivity
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM) . KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.
Smiles
C(N(C)C1=CC=C(C#N)C=C1)(=O)C2=CN3C(=CN=C3C=N2)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C22H14F3N5O
Molecular Weight
421.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide
CAS Number1513879-18-9
PubChem CID74767274
IUPAC NameN-(4-cyanophenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
Molecular FormulaC22H14F3N5O
Molecular Weight421.4
XLogP4.3
Topological Polar Surface Area74.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity691
SMILES
CN(C1=CC=C(C=C1)C#N)C(=O)C2=CN3C(=CN=C3C=N2)C4=CC=C(C=C4)C(F)(F)F
InChI
InChI=1S/C22H14F3N5O/c1-29(17-8-2-14(10-26)3-9-17)21(31)18-13-30-19(11-28-20(30)12-27-18)15-4-6-16(7-5-15)22(23,24)25/h2-9,11-13H,1H3
InChIKey
XAZOWMVYGFASLH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide
CAS: 1513879-18-9
CID: 74767274
Formula: C22H14F3N5O
MW: 421.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.4
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass421.11504457
Monoisotopic Mass421.11504457
Topological Polar Surface Area74.3 Ų
Heavy Atom Count31
Formal Charge0
Complexity691
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T71551-01KAI-1678
T204384-01KAI-11101
T28632-01RXP-407
T19524Poloxamer 407
T76429-01Neurokinin Receptor (393-407), rat
TMPY-06106-01SARS-CoV-2 Nucleocapsid Protein (aa 248-407, His)
T12062-01MK-4074

Alternative Products

CatalogName
HY-18746KAI-407
ABC-TC0452Intestine 407
MBS3614534-01Poloxamer 407
MBS5778309RXP-407
ARC0867SNU-407
HY-170484KAI-11101
MBS5814089KAI-1678
HY-123657RXP 407
HY-D1005-01Poloxamer 407 (F127)
116277LSNU-407 Cells

Popular Products