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KAI-407

CAT: 0931-T70507-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70507-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1513879-18-9
Target
Others
Related Pathways
Others
Bioactivity
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM) . KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.
Smiles
C(N(C)C1=CC=C(C#N)C=C1)(=O)C2=CN3C(=CN=C3C=N2)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C22H14F3N5O
Molecular Weight
421.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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