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KAI-407

CAT: 0804-HY-18746Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18746Size:1 Each
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Description
KAI-407 is an orally active inhibitor of Plasmodium PI4K kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC50s of for the blood stage of malignant Plasmodium of 81 nM; for the liver schizonts of P. yoelii of 88 nM; and IC50s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 μM and 0.69 μM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria[1][2].
CAS Number
1513879-18-9
UNSPSC
12352005
Target
Parasite; PI4K
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Field of Research
Infection
Smiles
O=C(C1=CN2C(C=N1)=NC=C2C3=CC=C(C(F)(F)F)C=C3)N(C4=CC=C(C#N)C=C4)C
Molecular Formula
C22H14F3N5O
Molecular Weight
421.37
References & Citations
[1]Zou B, et al. Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. ACS Med Chem Lett. 2014 Jul 6;5 (8) :947-50. |[2]Zeeman AM, et al. KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother. 2014;58 (3) :1586-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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