KAI-11101

• Target :

  P38 MAPK|||MAPK|||MAP3K

• Related Pathways :

  MAPK

• Bioactivity :

  KAI-11101 is an inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. It effectively suppresses paclitaxel-induced cJun phosphorylation (IC50=95 nM), thereby inhibiting the activation of the MAPK pathway. KAI-11101 exhibits blood-brain barrier permeability, allowing for further exploration of its neuroprotective properties.

• Smiles :

  CCN1C2=C(C=CN(C2=O)[C@@H]3CCC(C[C@@H]3OC)(F)F)C(=N1)C4=CC(=C(N=C4)N)OC(F)F

• Molecular Formula :

  C21H23F4N5O3

• Molecular Weight :

  469.433

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C