KAI-11101

• Target:

  P38 MAPK|||MAPK|||MAP3K

• Related Pathways:

  MAPK

• Bioactivity:

  KAI-11101 is an inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. It effectively suppresses paclitaxel-induced cJun phosphorylation (IC50=95 nM), thereby inhibiting the activation of the MAPK pathway. KAI-11101 exhibits blood-brain barrier permeability, allowing for further exploration of its neuroprotective properties.

• Smiles:

  CCN1C2=C (C=CN (C2=O) [C@@H]3CCC (C[C@@H]3OC) (F) F) C (=N1) C4=CC (=C (N=C4) N) OC (F) F

• Molecular Formula:

  C21H23F4N5O3

• Molecular Weight:

  469.433

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C