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NL-103

CAT: 931-T70195-01Size: 25 mgDry Ice: NoHazardous: No
25 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1788896-33-2
Target
HDAC|||Hedgehog/Smoothened|||Others
Related Pathways
Others|||GPCR/G Protein|||Stem Cells|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.
Smiles
N(C(=O)C1=CC(Cl)=CC=C1)C2=CC(NC(=O)C=3C=CC(NCCCCCCC(NO)=O)=NC3)=CC=C2Cl
Molecular Formula
C26H27Cl2N5O4
Molecular Weight
544.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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