TAS-108 citrate

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues.

• Smiles:

  C(CC(O)=O)(CC(O)=O)(C(O)=O)O.C[C@H]1[C@]2([C@]3([C@@](C)([C@@H](CCOC4=C(OC)C=C(CN(CC)CC)C=C4)CC3)CC[C@@]2(C=5C(C1)=CC(O)=CC5)[H])[H])[H]

• Molecular Formula:

  C39H55NO10

• Molecular Weight:

  697.86

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  229634-98-4