TAS-119

• Target:

  Aurora Kinase

• Related Pathways:

  Cell Cycle/Checkpoint|||Chromatin/Epigenetic

• Purity:

  0.9965

• Bioactivity:

  TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.

• Smiles:

  Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1

• Molecular Formula:

  C23H22Cl2FN5O3

• Molecular Weight:

  506.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1453099-83-6