TAS-119

CAT: 0931-T34787-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T34787-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1453099-83-6

Target

Aurora Kinase

Related Pathways

Cell Cycle/Checkpoint, Chromatin/Epigenetic

Purity

0.9965

Bioactivity

TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.

Smiles

Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1

Molecular Formula

C23H22Cl2FN5O3

Molecular Weight

506.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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TAS-119

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