TAS-119

CAT: 0931-MF-0019265-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0019265-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1453099-83-6
Target
Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint|||Chromatin/Epigenetic
Purity
0.9965
Bioactivity
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.
Smiles
Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
Molecular Formula
C23H22Cl2FN5O3
Molecular Weight
506.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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