PSB-KD477

CAT: 0931-MF-0144199-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0144199-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2488763-19-3
Target
Others
Related Pathways
Others
Bioactivity
PSB-KD477 is an Agonist of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. PSB-KD477 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent ?-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55. Structure-activity relationships were steep, and indole substitution was crucial for biological activity. These first selective agonists, which are structurally distinct from the lipidic agonist (s), will allow target validation studies and may eventually contribute to the deorphanization of GPR18.
Smiles
O=C1C=2N3C(=NC2N(C)C(=O)N1C)N(CCC=4C=5C(NC4)=CC=CC5)CCCC3
Molecular Formula
C21H24N6O2
Molecular Weight
392.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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