DBRD4-BD1

• Target :

  Others|||PROTACs|||Epigenetic Reader Domain

• Related Pathways :

  PROTAC|||Others|||Chromatin/Epigenetic

• Bioactivity :

  DBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM) . Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.

• Smiles :

  O(C=1N=C(C2=C(N=CN2C3CCN(CCOCCOCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)CC3)C7=CC=C(C(F)(F)F)C=C7)C=CN1)C8=CC(C(C)C)=CC=C8C

• Molecular Formula :

  C50H53F3N8O9

• Molecular Weight :

  967

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2839318-19-1