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HKI-357

CAT: 0931-T11569-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T11569-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
848133-17-5
Target
EGFR
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors
Purity
0.9991
Bioactivity
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM), effectively suppressing EGFR autophosphorylation (at Y1068), as well as AKT and MAPK phosphorylation.
Smiles
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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