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AM-3189

CAT: 0931-T68356-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68356-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
916219-50-6
Target
Others
Related Pathways
Others
Bioactivity
AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavailability. AM-3189 does not penetrate the rat CNS as indicated by a rat brain to plasma ratio of 0.04 at 3 h after an oral dose of 5 mg/kg.
Smiles
[C@H](CC(O)=O)(C1=CC=C(OCC2=CC(=CC=C2)C3=C(C)C=C(Cl)C=C3)C=C1)C=4N(C)C=CN4
Molecular Formula
C27H25ClN2O3
Molecular Weight
460.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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