Amrubicin HCl

CAT: 0931-MF-0065736-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0065736-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
92395-36-3
Target
Others|||Topoisomerase
Related Pathways
Others|||DNA Damage/DNA Repair
Bioactivity
Amrubicin, also known as SM-5887, is an anthracycline used in the treatment of lung cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. This agent has demonstrated a higher level of anti-tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative cardiac toxicity common to this class of compounds. It is marketed in Japan since 2002 by Sumitomo Pharmaceuticals.
Smiles
O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4)C[C@](C(C)=O)(N)C1)[C@@H]5C[C@H](O)[C@H](O)CO5
Molecular Formula
C25H25NO9
Molecular Weight
483.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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