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BNC105P

CAT: 0931-T68273-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68273-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
945771-96-0
Target
Others|||Microtubule Associated
Related Pathways
Others|||Cytoskeletal Signaling
Bioactivity
BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.
Smiles
[Na+].[Na+].COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(C)oc2c1OP([O-])([O-])=O
Molecular Formula
C20H21O10P
Molecular Weight
452.3485
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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