BNC105

CAT: 0931-T14694-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T14694-01Size:1 mg

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CAS Number

945771-74-4

Target

Microtubule Associated

Related Pathways

Cytoskeletal Signaling

Purity

0.9657

Bioactivity

BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.

Smiles

COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(C)oc2c1O

Molecular Formula

C20H20O7

Molecular Weight

372.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Bnc-105

Vascular Disrupting Agent BNC105 is a vascular disrupting agent (VDA), with potential anti-vascular and antineoplastic activities. Upon administration, vascular disrupting agent BNC105 binds to tubulin and inhibits its polymerization, which results in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. This deprives tumor cells of nutrients and results in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization.

CAS Number	945771-74-4
PubChem CID	24786555
IUPAC Name	(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone
Molecular Formula	C20H20O7
Molecular Weight	372.4
XLogP	3.6
Topological Polar Surface Area	87.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	27
Formal Charge	0
Complexity	499

SMILES

CC1=C(C2=C(O1)C(=C(C=C2)OC)O)C(=O)C3=CC(=C(C(=C3)OC)OC)OC

InChI

InChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3

InChIKey

RADMJHVVIZTENA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 945771-74-4

CID: 24786555

Formula: C20H20O7

MW: 372.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	372.4
XLogP3	3.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	372.12090297
Monoisotopic Mass	372.12090297
Topological Polar Surface Area	87.4 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	499
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
MBS3614595-01	BNC105
A20945-200	BNC105 200mg
A20945-25	BNC105 25mg
A20945-5	BNC105 5mg
A20945-1	BNC105 1mg
A20945-100	BNC105 100mg
A20945-50	BNC105 50mg
A20945-10	BNC105 10mg
A20945-10mM-D	BNC105 10mM * 1mL in DMSO

BNC105

Chemical Information

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