RO5068760

• CAS Number :

  947182-25-4

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP) -competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 ?M in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.

• Smiles :

  [C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=C(F)C=C(I)C=C2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OC[C@@H](CO)O)C=C4

• Molecular Formula :

  C28H27FIN3O6

• Molecular Weight :

  647.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C