RO5068760

CAT: 0013-GTR19211612-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19211612-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

RO5068760 is a potent, non-ATP-competitive, and highly selective MEK1/2 inhibitor of the substituted hydantoin class. It demonstrates strong in vitro activity (IC50 = 0.025 μM) and shows superior efficacy in vivo against tumors driven by aberrant MAPK signaling, particularly those harboring the B-Raf V600E mutation.

CAS Number

947182-25-4

Smiles

[C@H] ([C@@H] (C) C1=CC=CC=C1) (C (NC2=C (F) C=C (I) C=C2) =O) N3C (=O) [C@H] (NC3=O) C4=CC=C (OC[C@@H] (CO) O) C=C4

Molecular Formula

C28H27FIN3O6

Molecular Weight

647.43

Storage Conditions

-20°C

Notes

For research use only.