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RO5068760

CAT: 0804-HY-111033Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111033Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO5068760 is a potent, orally active and selective non-ATP-competitive MEK1/2 inhibitor with an IC50 of 0.025 μM for MEK1. RO5068760 significantly inhibits MAPK pathway activity, thereby inducing G1 cell cycle arrest and apoptosis to inhibit cancer cell growth. RO5068760 exhibits significant efficacy in a broad spectrum of tumors with aberrant MAPK pathway activation. RO5068760 can be used for melanoma, colorectal cancer, non-small cell lung cancer (NSCLC), and pancreatic cancer research[1].
CAS Number
947182-25-4
UNSPSC
12352005
Target
Apoptosis; CDK; ERK; MEK; p38 MAPK; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
C[C@@H](C1=CC=CC=C1)[C@H](N2C([C@@H](C3=CC=C(C=C3)OC[C@H](O)CO)NC2=O)=O)C(NC4=C(C=C(C=C4)I)F)=O
Molecular Formula
C28H27FIN3O6
Molecular Weight
647.43
References & Citations
[1]Daouti S, et al. Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models. Mol Cancer Ther. 2010 Jan;9 (1) :134-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1; MEK2

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CatalogName
T68267-01RO5068760

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