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Canfosfamide hydrochloride

CAT: 0931-T67975-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T67975-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
439943-59-6
Target
DNA Alkylator/Crosslinker, Others
Related Pathways
DNA Damage/DNA Repair, Others
Bioactivity
Canfosfamide Hydrochloride is the hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation.
Smiles
P(N(CCCl)CCCl)(N(CCCl)CCCl)(OCCS(C[C@@H](C(N[C@@H](C(O)=O)C1=CC=CC=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)(=O)=O)=O.Cl
Molecular Formula
C26H41Cl5N5O10PS
Molecular Weight
823.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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