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Canfosfamide (hydrochloride)

CAT: 0804-HY-16123Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16123Size:1 Each
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Description
Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.
CAS Number
439943-59-6
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/canfosfamide-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
ClCCN(CCCl)P(N(CCCl)CCCl)(OCCS(C[C@H](NC(CC[C@H](N)C(O)=O)=O)C(N[C@H](C1=CC=CC=C1)C(O)=O)=O)(=O)=O)=O.Cl
Molecular Formula
C26H41Cl5N5O10PS
Molecular Weight
823.94
References & Citations
[1]Dourado DF, Fernandes PA, Ramos MJ, Mannervik B. Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA) . Biochemistry. 2013;52 (45) :8069-8078. |[2]Satyam A, Hocker MD, Kane-Maguire KA, Morgan AS, Villar HO, Lyttle MH. Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase. J Med Chem. 1996;39 (8) :1736-1747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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