Products for Research Use Only
RegisterLogin

Canfosfamide

CAT: 0804-HY-16124Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-16124Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK) . Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies[1][2][3].
CAS Number
158382-37-7
Product Name Alternative
TLK-286; TER286
UNSPSC
12352005
Target
Apoptosis; DNA-PK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/canfosfamide.html
Solubility
10 mM in DMSO
Smiles
ClCCN(CCCl)P(N(CCCl)CCCl)(OCCS(C[C@H](NC(CC[C@H](N)C(O)=O)=O)C(N[C@H](C1=CC=CC=C1)C(O)=O)=O)(=O)=O)=O
Molecular Formula
C26H40Cl4N5O10PS
Molecular Weight
787.47
References & Citations
[1]Dourado DF, et al. Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA) . Biochemistry. 2013 Nov 12;52 (45) :8069-78.|[2]Tew KD. TLK-286: a novel glutathione S-transferase-activated prodrug. Expert Opin Investig Drugs. 2005 Aug;14 (8) :1047-54.|[3]Morgan AS, et al. Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase. Cancer Res. 1998 Jun 15;58 (12) :2568-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
T75245-01Canfosfamide
MBS5810548canfosfamide hydrochloride

Popular Products