BMS-903452

• Target :

  GPCR

• Related Pathways :

  GPCR/G Protein|||Endocrinology/Hormones

• Purity :

  >99.99%

• Bioactivity :

  BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 ?M), does not activate PXR (EC50 > 50 ?M), and is not toxic to liver (HEPG2) cell lines.

• Smiles :

  O=C1N(C=C(Cl)C(OC2CCN(CC2)C=3N=CC(Cl)=CN3)=C1)C4=C(F)C=C(S(C)(=O)=O)C=C4

• Molecular Formula :

  C21H19Cl2FN4O4S

• Molecular Weight :

  513.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1339944-47-6