BMS-554417

CAT: 0931-T69221-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T69221-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
468741-42-6
Target
Others
Related Pathways
Others
Bioactivity
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202) . BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosphorylation at Ser473. At doses that inhibited proliferation, the compound also caused a G0-G1 arrest and prevented nuclear accumulation of cyclin D1 in response to LR3 IGF-I. In Jurkat T-cell leukemia cells, this agent triggered apoptotic cell death via the mitochondrial pathway. BMS-554417 was orally bioavailable and significantly inhibited the growth of IGF1R-Sal tumor xenografts in vivo. BMS-554417 is a member of a novel class of IGF-IR/insulin receptor inhibitors that have potential......
Smiles
N(C[C@@H](O)C1=CC(Cl)=CC=C1)C2=C(C=3NC=4C(N3)=CC(=CC4C)N5CCN(CCC#N)CC5)C(=O)NC=C2
Molecular Formula
C28H30ClN7O2
Molecular Weight
532.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T9164-01BMS-986242
T4016-01BMS-986020
T26863-01BMS-929075
T30522-01BMS-422461
T26841-01BMS 182874
T30517-01BMS-354326
T30537-01BMS-694153
T30509BMS-247243
T30544-01BMS-919373
T30525-01BMS-442608

Alternative Products

CatalogName
MBS5811771BMS-554417
MBS386661-01BMS-806 (BMS 378806)
A11201-1BMS-806 (BMS 378806) 1mg
A11201-2BMS-806 (BMS 378806) 2mg
A11201-500BMS-806 (BMS 378806) 500mg
A11201-25BMS-806 (BMS 378806) 25mg
MBS3616196-01BMS 193885
MBS3607783-01BMS-833923
MBS3607487-01BMS-378806
MBS3602996-01BMS-986195

Popular Products