RUNX1/ETO tetramerization-IN-1

CAT: 0931-T61098-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T61098-01Size:2 mg

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CAS Number

88755-39-9

Target

Others

Related Pathways

Others

Bioactivity

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor targeting NHR2 of RUNX1/ETO, effectively inhibiting tetramerization with an EC50 value of 0.25 μM. This compound restores gene expression down-regulated by RUNX1/ETO and demonstrates anti-leukemic activity by inhibiting proliferation of RUNX1/ETO-dependent SKNO-1 cells and reducing tumor growth in a mouse model [1] [2] [3].

Smiles

C(CC(=O)C=1C=C2C(=CC1)OCO2)(C(O)=O)C=3C=C4C(=CC3)OCO4

Molecular Formula

C18H14O7

Molecular Weight

342.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

2,4-Bis(1,3-benzodioxol-5-yl)-4-oxobutanoic acid

CAS Number	88755-39-9
PubChem CID	294348
IUPAC Name	2,4-bis(1,3-benzodioxol-5-yl)-4-oxobutanoic acid
Molecular Formula	C18H14O7
Molecular Weight	342.3
XLogP	2.4
Topological Polar Surface Area	91.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	25
Formal Charge	0
Complexity	522

SMILES

C1OC2=C(O1)C=C(C=C2)C(CC(=O)C3=CC4=C(C=C3)OCO4)C(=O)O

InChI

InChI=1S/C18H14O7/c19-13(11-2-4-15-17(6-11)25-9-23-15)7-12(18(20)21)10-1-3-14-16(5-10)24-8-22-14/h1-6,12H,7-9H2,(H,20,21)

InChIKey

PPEBBOHQEAQKSW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 88755-39-9

CID: 294348

Formula: C18H14O7

MW: 342.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	342.3
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	342.07395278
Monoisotopic Mass	342.07395278
Topological Polar Surface Area	91.3 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	522
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T210892-01	RUNX1/ETO-IN-1
TMAC-03660-01	Anti-RUNX1/RUNX2/RUNX3/RUNX2/RUNX3 Antibody (4N296)
TMAB-12426-01	Anti-RUNX1/RUNX2/RUNX3 Antibody (1I929)
TMAB-12421-01	Anti-RUNX1/AML1+RUNX3+RUNX2 Polyclonal Antibody
TMAB-12422-01	Anti-RUNX1+RUNX2 Polyclonal Antibody
TMAB-12425-01	Anti-RUNX1 Polyclonal Antibody
TMAB-12423-01	Anti-RUNX1 Polyclonal Antibody 2
TMAB-12424-01	Anti-RUNX1 Polyclonal Antibody 3
TMAC-00176-01	Anti-Phospho-RUNX1 (Ser303) Polyclonal Antibody
TMPH-03366-01	RUNX1 Protein, Rat, Recombinant (His & Myc)

Alternative Products

Catalog	Name
HY-151411-01	RUNX1/ETO tetramerization-IN-1
GTR19263396-01	RUNX1/ETO-IN-1
FP-004	ETO /AML 1
HY-124137-01	Runx1-CBFβ interaction inhibitor 1
AB-23111-P	Human Runt-related transcription factor 1 (RUNX1) control (RUNX1- phospho) peptide
NBP2-73956CL1	Mouse Monoclonal RUNX1T1/ETO Antibody (OTI1H1) [CoraFluor 1]
AB-23267-P	Rat runt related transcription factor 1 (RUNX1) control (RUNX1- asymmetric dimethyl) peptide
491062	RUNX1 (Runt-Related Transcription Factor 1)
PX-P4688-01	Runt-related transcription factor 1 (RUNX1)
SIPD878Hu01-01	Recombinant Runt Related Transcription Factor 1 (RUNX1)

RUNX1/ETO tetramerization-IN-1

Chemical Information

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