RUNX1/ETO tetramerization-IN-1

CAT: 0931-T61098-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T61098-01Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

88755-39-9

Target

Others

Related Pathways

Others

Bioactivity

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor targeting NHR2 of RUNX1/ETO, effectively inhibiting tetramerization with an EC50 value of 0.25 μM. This compound restores gene expression down-regulated by RUNX1/ETO and demonstrates anti-leukemic activity by inhibiting proliferation of RUNX1/ETO-dependent SKNO-1 cells and reducing tumor growth in a mouse model [1] [2] [3].

Smiles

C(CC(=O)C=1C=C2C(=CC1)OCO2)(C(O)=O)C=3C=C4C(=CC3)OCO4

Molecular Formula

C18H14O7

Molecular Weight

342.3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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RUNX1/ETO tetramerization-IN-1

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