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RUNX1/ETO-IN-1

CAT: 0013-GTR19263396-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263396-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RUNX1/ETO-IN-1 is an inhibitor targeting the oncogenic fusion protein RUNX1-ETO, specifically affecting the NHR2 oligomerization domain. It binds directly to NHR2 (KD, app = 39 μM) . By inducing apoptosis and promoting differentiation, RUNX1/ETO-IN-1 exhibits antileukemic activity in RUNX1/ETO translocation acute myeloid leukemia (AML) cells. Its near-neutral charge under physiological pH conditions grants it excellent cell membrane permeability.
CAS Number
923865-06-9
Field of Research
Cancer Biology, Cell Biology
Smiles
O=C1C=C (N=C2SC=C (N12) C) CNC (C3=CC=C4OCCCOC4=C3) C (C) C
Molecular Formula
C21H25N3O3S
Molecular Weight
399.51
Storage Conditions
-20°C
Notes
For research use only.

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