KOR agonist 6

CAT: 0931-T212523-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T212523-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Opioid Receptor

Related Pathways

GPCR/G Protein, Endocrinology/Hormones, Neuroscience

Bioactivity

KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTPγS binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower β-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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KOR agonist 6

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