KOR agonist 6

CAT: 0931-MF-0119470-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0119470-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Opioid Receptor
Related Pathways
GPCR/G Protein|||Endocrinology/Hormones|||Neuroscience
Bioactivity
KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTP?S binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower ?-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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