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PDGFRα kinase-IN-2

CAT: 0931-T212468-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212468-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3066103-58-7
Target
PDGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.
Smiles
O=C(NC1=CC=C(C=C1)NC=2N=CN=C3C=C(OC)C(OC)=CC32)NC4=CC=CC(=C4)C
Molecular Formula
C24H23N5O3
Molecular Weight
429.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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