Products for Research Use Only
RegisterLogin

PDGFRα kinase-IN-2

CAT: 0013-GTR19264656-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19264656-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.
CAS Number
3066103-58-7
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C (NC1=CC=C (C=C1) NC=2N=CN=C3C=C (OC) C (OC) =CC32) NC4=CC=CC (=C4) C
Molecular Formula
C24H23N5O3
Molecular Weight
429.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-3-(3-methylphenyl)urea
CAS Number3066103-58-7
PubChem CID176081526
IUPAC Name1-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]-3-(3-methylphenyl)urea
Molecular FormulaC24H23N5O3
Molecular Weight429.5
XLogP4.3
Topological Polar Surface Area97.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity600
SMILES
CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC
InChI
InChI=1S/C24H23N5O3/c1-15-5-4-6-18(11-15)29-24(30)28-17-9-7-16(8-10-17)27-23-19-12-21(31-2)22(32-3)13-20(19)25-14-26-23/h4-14H,1-3H3,(H,25,26,27)(H2,28,29,30)
InChIKey
ZXLGTQIIRZVORL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-[4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenyl]-3-(3-methylphenyl)urea
CAS: 3066103-58-7
CID: 176081526
Formula: C24H23N5O3
MW: 429.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.5
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass429.18008961
Monoisotopic Mass429.18008961
Topological Polar Surface Area97.4 Ų
Heavy Atom Count32
Formal Charge0
Complexity600
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19205180-01PDGFRα kinase inhibitor 1
GTR19258583-01PDGFRα kinase inhibitor 3
GTR19188295-01PDGFR Tyrosine Kinase Inhibitor III
GTR19262414-01PDGFRα/β/VEGFR-2-IN-1
GTR19185009-01PDGFRα/FLT3-ITD-IN-2
GTR18224379PDGFRB/PDGFR Beta Antibody
GTR18221829PDGFRA/PDGFR Alpha Antibody
GTR18221789PDGFRA/PDGFR Alpha Antibody
GTR18221818PDGFRA/PDGFR Alpha Antibody
GTR18225305PDGFRB/PDGFR Beta Antibody

Alternative Products

CatalogName
HY-175540PDGFRα kinase-IN-2
HY-W143698-01PDGFRα kinase inhibitor 2
HY-42933-01PDGFR-IN-2
HY-173275PDGFRα kinase inhibitor 3
T12396PDGFRα kinase inhibitor 1
sc-364570PDGFRβ/RAF Kinase Inhibitor
HY-112412-01PDGFR Tyrosine Kinase Inhibitor III
sc-205794PDGFR Tyrosine Kinase Inhibitor IV
TBI1087-25MGAG-1296, PDGFR kinase inhibitor
BKA35645-01PDGFR Tyrosine Kinase Inhibitor VII

Popular Products