MCB-22-174

CAT: 0931-MF-0115588-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0115588-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3058199-58-6
Target
Others|||ERK|||Piezo Channel|||CaMK
Related Pathways
Neuroscience|||Others|||MAPK|||Membrane transporter/Ion channel
Bioactivity
MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM) -dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP) .
Smiles
S(C(C1=C(Cl)C=CC=C1Cl)[2H])C=2SC(=NN2)C=3C=NC(NC[C@@H](C)O)=CN3
Molecular Formula
C16H14DCl2N5OS2
Molecular Weight
429.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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