MCB-22-174

• Target:

  Others|||ERK|||Piezo Channel|||CaMK

• Related Pathways:

  Neuroscience|||Others|||MAPK|||Membrane transporter/Ion channel

• Bioactivity:

  MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM) -dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP) .

• Smiles:

  S(C(C1=C(Cl)C=CC=C1Cl)[2H])C=2SC(=NN2)C=3C=NC(NC[C@@H](C)O)=CN3

• Molecular Formula:

  C16H14DCl2N5OS2

• Molecular Weight:

  429.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3058199-58-6