Carmaphycin-17

• Target:

  Proteasome|||Parasite

• Related Pathways:

  Microbiology/Virology|||Proteases/Proteasome|||Ubiquitination

• Bioactivity:

  Carmaphycin-17 (CP-17) is a selective proteasome inhibitor with an EC50 of 217 nM. It exhibits potent antimicrobial activity against Trichomonas vaginalis and can overcome resistance to Metronidazole. In mouse models of vaginal trichomoniasis, CP-17 significantly reduces parasite burden after topical treatment without any observed adverse effects. Additionally, Carmaphycin-17 is useful for researching sexually transmitted diseases like trichomoniasis.

• Smiles:

  C([C@@H](C(N[C@H](C(=O)[C@@]1(C)CO1)CC2=CC=CC=C2)=O)NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC(CCCCC)=O)=O)C=5C=6C(NC5)=CC=CC6

• Molecular Formula:

  C40H45N5O5

• Molecular Weight:

  675.82

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2143080-91-3