Carmaphycin-17

CAT: 0804-HY-171956Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171956Size:1 Each
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Description
Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research[1].
CAS Number
[2143080-91-3]
UNSPSC
12352005
Target
Parasite; Proteasome
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C([C@]1(CO1)C)[C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CCCCC)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CNC6=CC=CC=C56)=O
Molecular Formula
C40H45N5O5
Molecular Weight
675.82
References & Citations
[1]O'Donoghue AJ, et al. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 Oct 22;63 (11) :e00448-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T211949-01Carmaphycin-17
MBS393792-01Heptadecanoic-17,17,17-D3 Acid
138536-01Cytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17)
138536-AF-PECytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (PE)
138536-AF-APCCytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (APC)
138536-AF-FITCCytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (FITC)
MBS6122207-01Cytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (AP)
MBS6122211-01Cytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (HRP)
138536-AF-BiotinCytokeratin 17 (Cytokeratin-17, CK 17, CK17, CK-17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17) (Biotin)
MBS343180-01Interleukin-17 (IL-17)

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