Carmaphycin-17

• Description :

  Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research[1].

• UNSPSC :

  12352005

• Target :

  Parasite; Proteasome

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Smiles :

  O=C([C@]1(CO1)C)[C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CCCCC)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CNC6=CC=CC=C56)=O

• Molecular Formula :

  C40H45N5O5

• Molecular Weight :

  675.82

• References & Citations :

  [1]O'Donoghue AJ, et al. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 Oct 22;63 (11) :e00448-19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2143080-91-3]