IOR-160

CAT: 0013-GTR19264178-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19264178-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.

CAS Number

2421119-78-8

Field of Research

Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Stem Cell & Developmental Biology

Smiles

O=C (O) C=1C=CC2=C (N=C (NCCCCCCCC (=O) NO) C=3C=CN=CC23) C1.O=C (O) C (F) (F) F

Molecular Formula

C23H25F3N4O6

Molecular Weight

510.46

Storage Conditions

-20°C

Notes

For research use only.

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