BRD4-IN-11

• Target:

  Apoptosis|||Phosphatase|||Epigenetic Reader Domain|||c-Myc

• Related Pathways:

  Cell Cycle/Checkpoint|||Metabolism|||Apoptosis|||Chromatin/Epigenetic

• Bioactivity:

  BRD4-IN-11 is an orally active and selective inhibitor of BRD4 with an IC50 of 26.35 nM for BD1 and 72.81 nM for BD2. Its potency against BRD4 is approximately 3 to 18 times greater than against BRr2, BRD3, and BRDT. BRD4-IN-11 increases H2S release and inhibits the upregulation of fibrosis markers (?-SMA and fibronectin), c-Myc, and CDC25B. It also reduces apoptosis in LO2 hepatic cells. In liver and lung fibrosis models, BRD4-IN-11 significantly improves liver and lung function, making it suitable for research on liver and lung fibrosis.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C