PI3Kδ-IN-24

CAT: 0931-T211388-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211388-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3051829-20-7

Target

PI3K, Akt, Apoptosis

Related Pathways

PI3K/Akt/mTOR signaling, Apoptosis, Cytoskeletal Signaling

Bioactivity

PI3Kδ-IN-24 is a selective inhibitor of PI3Kδ with an IC50 value of 0.1 nM. It exhibits significant antiproliferative effects on cancer cell lines that overexpress PI3Kδ. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. This compound is applicable for cancer research, particularly in diffuse large B-cell lymphoma (DLBCL) .

Smiles

N([C@H](C(=O)N1CCN(C)CC1)C)C=2C3=C(C=CC(=N3)C=4C=C(C(OC5=CC=CC=C5)=O)C(OC)=NC4)N=CN2

Molecular Formula

C28H29N7O4

Molecular Weight

527.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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PI3Kδ-IN-24

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