YZ-35

CAT: 0931-T211347-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211347-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, STAT

Related Pathways

Apoptosis, JAK/STAT signaling, Stem Cells

Bioactivity

YZ-35 is a STAT3 inhibitor with a Ki value of 0.38 μM. It binds directly to STAT3 with high affinity, having a dissociation constant (Kd) of 190 nM. YZ-35 effectively inhibits the dual phosphorylation of STAT3 at Tyr705 and Ser727 sites. It also suppresses colony formation, cell migration, and induces apoptosis in breast cancer cell lines. Additionally, YZ-35 selectively inhibits the self-renewal capability of breast cancer stem cells (BCSC) and reduces tumor growth in breast cancer stem cell xenograft models. YZ-35 is applicable for breast cancer research.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-175253	YZ-35
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YZ-35

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