YZ-35

• Target :

  Apoptosis|||STAT

• Related Pathways :

  Apoptosis|||JAK/STAT signaling|||Stem Cells

• Bioactivity :

  YZ-35 is a STAT3 inhibitor with a Ki value of 0.38 ?M. It binds directly to STAT3 with high affinity, having a dissociation constant (Kd) of 190 nM. YZ-35 effectively inhibits the dual phosphorylation of STAT3 at Tyr705 and Ser727 sites. It also suppresses colony formation, cell migration, and induces apoptosis in breast cancer cell lines. Additionally, YZ-35 selectively inhibits the self-renewal capability of breast cancer stem cells (BCSC) and reduces tumor growth in breast cancer stem cell xenograft models. YZ-35 is applicable for breast cancer research.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C