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MAO-B-IN-45

CAT: 0931-T211128-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211128-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3069915-36-9
Target
Microtubule Associated, Monoamine Oxidase, ROS, Glutathione Peroxidase, Beta Amyloid, Ferroptosis
Related Pathways
Metabolism, Immunology/Inflammation, Cytoskeletal Signaling, Neuroscience, Apoptosis
Bioactivity
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3xTg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.
Smiles
O=C1C(O)=CC=2C=CC(OCC3=CC=C(Cl)C=C3)=CC2N1C
Molecular Formula
C17H14ClNO3
Molecular Weight
315.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-176271MAO-B-IN-45
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