ML-20

• Target :

  Autophagy|||Apoptosis

• Related Pathways :

  Apoptosis|||Autophagy

• Bioactivity :

  ML-20, an analog of Malabaricone C, functions as both an autophagy inhibitor and a radiosensitizer. It suppresses cell proliferation and induces apoptosis (cell death) . ML-20 also causes DNA double-strand breaks, loss of mitochondrial membrane potential (MMP), and lysosomal membrane permeabilization (LMP) . Due to LMP, it triggers endoplasmic reticulum stress while concurrently inhibiting autophagic flux.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C