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EIF4E/eIF4G PPI-IN-1

CAT: 0013-GTR19263489-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263489-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EIF4E/eIF4G PPI-IN-1 is an inhibitor that disrupts the interaction between eIF4E and eIF4G, exhibiting a dissociation constant (KD) of 20.2 μM for the eIF4E protein. It demonstrates antitumor effects through various mechanisms, including modulation of eIF4E activity via inhibition of the Ras/MAPK/eIF4E signaling pathway, influencing apoptosis and cell migration. Additionally, eIF4E/eIF4G PPI-IN-1 inhibits the growth of HepG2 xenografted tumors in nude mice and is relatively non-toxic to mice.
Field of Research
Cell Biology, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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