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Keap1-IN-2

CAT: 0931-T210959-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210959-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3066895-41-5
Target
Nrf2
Related Pathways
Immunology/Inflammation
Bioactivity
Keap1-IN-2 (Compound 164) is an inhibitor of KEAP1 with an IC50 of 2 nM. It indirectly activates Nrf2 by blocking KEAP1, thereby enhancing cellular antioxidant capacity. By preventing KEAP1-mediated degradation of Nrf2, Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2. This compound is used in research on diseases related to oxidative stress, such as inflammatory bowel disease, Crohn's disease, and ulcerative colitis, which are immune-related conditions.
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C(C)(=O)N1[C@@H](CN(C(C=C)=O)C[C@H]1C)C=2C=C(N=C(Cl)C2)C=3C=C(C(NC)=O)N=CN3
Molecular Formula
C21H23ClN6O3
Molecular Weight
442.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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