Keap1-IN-2

• Target:

  Nrf2

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  Keap1-IN-2 (Compound 164) is an inhibitor of KEAP1 with an IC50 of 2 nM. It indirectly activates Nrf2 by blocking KEAP1, thereby enhancing cellular antioxidant capacity. By preventing KEAP1-mediated degradation of Nrf2, Keap1-IN-2 promotes the accumulation and nuclear translocation of Nrf2. This compound is used in research on diseases related to oxidative stress, such as inflammatory bowel disease, Crohn's disease, and ulcerative colitis, which are immune-related conditions.

• Smiles:

  C(C)(=O)N1[C@@H](CN(C(C=C)=O)C[C@H]1C)C=2C=C(N=C(Cl)C2)C=3C=C(C(NC)=O)N=CN3

• Molecular Formula:

  C21H23ClN6O3

• Molecular Weight:

  442.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3066895-41-5