Keap1-IN-1

• Target:

  Nrf2|||Reductase

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||Endocrinology/Hormones

• Bioactivity:

  Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.

• Smiles:

  CCP1(=O)CCN(CC1)C2=C(N=C(S2)S(=O)(=O)CC)S(=O)(=O)C3=C(C(=CC=C3)Cl)Cl

• Molecular Formula:

  C17H21Cl2N2O5PS3

• Molecular Weight:

  531.434

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C