PVTX-321

CAT: 0931-MF-0118049-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118049-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3026004-38-3
Target
Estrogen Receptor/ERR
Related Pathways
Endocrinology/Hormones
Bioactivity
PVTX-321 is an orally active estrogen receptor ? (ER?) degrader. It effectively degrades ER? with a DC50 of 0.15 nM in MCF-7 cells and also shows inhibitory activity against ER? mutants with an IC50 of 59 nM. PVTX-321 holds potential for research in ER+/HER2- breast cancer.
Smiles
C(N1CCC2(C=3C(OC2)=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)CC1)C6CC7(C6)CCN(CC7)C8=CC(OC)=C(C=C8F)[C@H]9[C@H](CCC=%10C9=CC=C(O)C%10)C%11=CC=CC=C%11
Molecular Formula
C51H55FN4O6
Molecular Weight
839
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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