PVTX-321

• Target :

  Estrogen Receptor/ERR

• Related Pathways :

  Endocrinology/Hormones

• Bioactivity :

  PVTX-321 is an orally active estrogen receptor ? (ER?) degrader. It effectively degrades ER? with a DC50 of 0.15 nM in MCF-7 cells and also shows inhibitory activity against ER? mutants with an IC50 of 59 nM. PVTX-321 holds potential for research in ER+/HER2- breast cancer.

• Smiles :

  C(N1CCC2(C=3C(OC2)=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)CC1)C6CC7(C6)CCN(CC7)C8=CC(OC)=C(C=C8F)[C@H]9[C@H](CCC=%10C9=CC=C(O)C%10)C%11=CC=CC=C%11

• Molecular Formula :

  C51H55FN4O6

• Molecular Weight :

  839

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3026004-38-3