LGB-321 HCl

CAT: 0931-MF-0145463-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145463-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1210416-93-5
Target
Others
Related Pathways
Others
Bioactivity
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor) . LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cell NHL. In vivo, LGB-321 is orally available, demonstrates efficacy in tumor xenografts and is well-tolerated within the therapeutic exposure range in mice. (source: Clin Cancer Res. 2014 Apr 1;20 (7) :1834-45)
Smiles
Cl.C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Molecular Formula
C23H23ClF3N5O2
Molecular Weight
493.91
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
MF-0034335-01Z-321
MF-0118049-01PVTX-321
MF-0039349-01AL-321
MF-0143208-01IMP-321
MF-0085011-01Anti-Phospho-FOXO3 (Ser318, 321) Polyclonal Antibody
MF-0145873-01Setastine HCl
MF-0145818-01Pirarubicin HCl
MF-0145723-01GSK2018682 HCl
MF-0145643-01Nemorubicin HCL
MF-0098537-01Lanperisone HCl

Alternative Products

CatalogName
MBS3600786-01LGB-321
MBS3840360-01LGB-321 HCl
A14420-25LGB-321 HCl 25mg
A14420-10LGB-321 HCl 10mg
A14420-5LGB-321 HCl 5mg
OACA02655-100UGLGB Antibody
CAC08262-01Lgb Polyclonal Antibody
TRC-G797305-2.5MGGSK 321
HY-174131PVTX-321
HY-19123-01Z-321

Popular Products