PVTX-405

• Target :

  Molecular Glues|||IKZF|||Potassium Channel

• Related Pathways :

  PROTAC|||Immunology/Inflammation|||Membrane transporter/Ion channel

• Bioactivity :

  PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.

• Smiles :

  C(N1CCC2(C=3C(OC2)=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)CC1)C6=CC(=CC=C6)C7=CN(C)N=C7

• Molecular Formula :

  C30H31N5O4

• Molecular Weight :

  525.6

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2991021-08-8