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PROTAC JAK2 degrader-1

CAT: 0931-T210842-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210842-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
STAT, JAK
Related Pathways
JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
PROTAC JAK2 degrader-1 (Compound 10i) is a JAK2 PROTAC degrader with a DC50 of 27.35 nM against JAK2V617F. It facilitates the ubiquitination and degradation of JAK2. This compound also inhibits the phosphorylation of JAK2, STAT3, and STAT5, and is applicable in the study of myeloproliferative neoplasms.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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